Functional and metabolic activity of blood neutrophilic granulocytes in children with erosive and ulcerative lesions of the stomach and duodenum with detected <i>Helicobacter pylori</i> infection

The Helicobacter pylori bacterium is currently considered one of the leading etiopathogenetic factors in formation gastric and duodenal ulcer children adults. Despite many studies this area, mechanisms phagocytic activity response to exposure are not completely clear. aim work was obtain results on functional metabolic blood neutrophilic granulocytes with -associated erosive ulcerative lesions stomach duodenum. object study isolated from patients control group. Samples were taken 46 persons – duodenum aged 11 18 years group, which consisted 55 practically healthy who had disease excluded same age range. A comparative analysis cells using chemiluminescent by bioluminescent method carried out. Luminol used as a chemiluminescence activator. measurement phagocytes based determination base (spontaneous reaction) reserve capacity when they exposed nonspecific inducer zymosan. There reduced activation index neutrophils relative may characterize reserves cells. In granulocytes, there decrease G6PDG, an enzyme that triggers glycolysis along pentose phosphate pathway contributes reduction nicotinamide adenine dinucleotide (NADP) NADPH, necessary for glutathione binds oxidants. With its insufficiency, energy occurs. H. infection, observed, associated inhibition processes